Endometrial cancer medical therapy
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Endometrial cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Endometrial cancer medical therapy On the Web |
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American Roentgen Ray Society Images of Endometrial cancer medical therapy |
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Risk calculators and risk factors for Endometrial cancer medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
Medical Therapy
| Risk | Risk definition | Management | Additional notes |
|---|---|---|---|
| Low risk | • Stage IA endometrial cancer • Well differentiated endometroid histology • Tumor confined to endometrium |
Total hysterectomy, bilateral salpingo-oophorectomy, and lymph node evaluation | • Women that opt for preservation of fertility may be candidates for medical therapy • Adjuvant therapy not indicated |
| Intermediate risk | • Stage I (tumor invades myometrium) or • Stage II (tumor demonstrates cervical stroma invasion) • Tumor usually moderately differentiated or poorly differentiated |
• Total hysterectomy, bilateral salpingo-oophorecomy, and lymph node evaluation • Adjuvant radiotherapy is indicated for patients with risk factors |
• No data available to recommend adjuvant chemotherapy in these patients • Observation recommended instead of adjuvant radiotherapy if patient has no risk factors |
| High risk | • Stage III or higher or • Any stage with serous or clear cell carcinoma |
• For stage I and II, surgery may be followed by adjuvant vaginal brachytherapy • For stage III and IV, surgery should be followed by adjuvant chemotherapy and pelvic radiotherapy |
Giving adjuvant brachytherapy for the high risk early staged tumors depends on patient and provider preferences |