Mantle cell lymphoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
There are no established risk factors for mantle cell lymphoma. However, recently weak associations have been observed in the development of mantle cell lymphoma with the exposure to European strains of Borellia burgdoferi. family history of hematologic malignancy and Genetic polymorphisms in the pro-inflammatory cytokine IL-10.
Risk Factors
- There are no established risk factors for mantle cell lymphoma. Although, the pathogenesis of mantle cell lymphoma at the cellular level is quite well understood now, there is not enough information on the risk factors that precipitate the cellular events.
- However, recently weak associations have been observed in the development of mantle cell lymphoma with the following:
- With exposure to European strains of Borellia burgdoferi.[1]
- Family history of hematologic malignancy.[2]
- Genetic polymorphisms in the pro-inflammatory cytokine IL-10.[3]
References
- ↑ Schöllkopf C, Melbye M, Munksgaard L, Smedby KE, Rostgaard K, Glimelius B; et al. (2008). "Borrelia infection and risk of non-Hodgkin lymphoma". Blood. 111 (12): 5524–9. doi:10.1182/blood-2007-08-109611. PMC 2972577. PMID 18424667.
- ↑ Wang SS, Slager SL, Brennan P, Holly EA, De Sanjose S, Bernstein L; et al. (2007). "Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)". Blood. 109 (8): 3479–88. doi:10.1182/blood-2006-06-031948. PMC 1852242. PMID 17185468.
- ↑ Skibola CF, Bracci PM, Nieters A, Brooks-Wilson A, de Sanjosé S, Hughes AM; et al. (2010). "Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium". Am J Epidemiol. 171 (3): 267–76. doi:10.1093/aje/kwp383. PMC 2842204. PMID 20047977.