Guillain-Barré syndrome medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyamvada Singh, MBBS [2]

Overview

With prompt treatment of plasmapheresis followed by immunoglobulins and supportive care, the majority of patients will regain full functional capacity. However, death may occur if severe pulmonary complications and dysautonomia are present.

Medical Therapy

• Treatment for Guillan Barre syndrome can be divided into two groups:
  • Supportive therapy:
    • Respiratory assistance: WE measure maximal expiratory vital capacity and if vital capacity falls under 15 ml/kg we start mechanical ventilation and endotracheal intubation.
    • Heart rate and blood pressure monitoring.
    • Prevention of thromboembolic complications by heparin.
    • Reduce respiratory infections by minimal sedation in intensive care units.
    • Pain control by analgesics.
    • Prevention of contracture by early passive movement.
  • Immunomodulating therapy
    • Plasma exchange: It is proved in so many studies that plasma exchange is an effective treatment option and can reduce recovery time.
    • High dose immunoglobulin
    • Corticosteroids