Mantle cell lymphoma laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing and FISH.
Laboratory tests
Laboratory tests for mantle cell lymphoma include:[1]
- Complete blood count (CBC) with differential count
- Pancytopenia or a leukemic presentation with extensive leukocytosis.[2]
- Comprehensive metabolic panel[3]
- LDH levels[4]: Normal range is 100–190 U/L
- Hepatitis B testing if treatment with rituximab is planned[5]
- Uric acid levels: Normal range is 2.4-6.0 mg/dL in females and 3.4-7.0 mg/dL in males.
- Beta-2-microglobulin[6]: Normal range is 0-3 µg/mL.
- Pregnancy testing in woman of child-bearing age
- Flow cytometry
- Immunohistochemistry[7][8]
- Translocation t(11;14)(q13;q32) in virtually all cases
- Mutation or deletions of ATM gene
- FISH (fluorescence in situ hybridization):
- FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients.[10]
References
- ↑ https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf
- ↑ Ana Ferrer, Itziar Salaverria, Francesc Bosch, Neus Villamor, Maria Rozman, Silvia Bea, Eva Gine, Armando Lopez-Guillermo, Elias Campo & Emili Montserrat (2007). "Leukemic involvement is a common feature in mantle cell lymphoma". Cancer. 109 (12): 2473–2480. doi:10.1002/cncr.22715. PMID 17477385. Unknown parameter
|month=ignored (help) - ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter
|month=ignored (help) - ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter
|month=ignored (help) - ↑ Arturo Ciccullo, F. R. Ponziani, E. Maiolo, F. Pallavicini & M. Pompili (2018). "Late reactivation of hepatitis B virus after rituximab-containing chemotherapy for mantle cell lymphoma: a case report". Infection. doi:10.1007/s15010-018-1242-1. PMID 30368733. Unknown parameter
|month=ignored (help) - ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter
|month=ignored (help) - ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter
|month=ignored (help) - ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter
|month=ignored (help) - ↑ Jordi Camps, Itziar Salaverria, Maria J. Garcia, Esther Prat, Silvia Bea, Jessica C. Pole, Lluis Hernandez, Javier Del Rey, Juan Cruz Cigudosa, Marta Bernues, Carlos Caldas, Dolors Colomer, Rosa Miro & Elias Campo (2006). "Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines". Leukemia research. 30 (8): 923–934. doi:10.1016/j.leukres.2005.11.013. PMID 16448697. Unknown parameter
|month=ignored (help) - ↑ Tsieh Sun, Mary Lowery Nordberg, James D. Cotelingam, Diana M. Veillon & John Ryder (2003). "Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma". American journal of hematology. 74 (1): 78–84. doi:10.1002/ajh.10356. PMID 12949897. Unknown parameter
|month=ignored (help)