Type II collagen
| collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | |
|---|---|
| Identifiers | |
| Symbol | COL2A1 |
| Alt. symbols | SEDC |
| Entrez | 1280 |
| HUGO | 2200 |
| OMIM | 120140 |
| RefSeq | NM_001844 |
| UniProt | P02458 |
| Other data | |
| Locus | Chr. 12 q13.11-q13.2 |
Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains.
It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.
Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.[1][2]
See also
References
- ↑ Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology. 19 (6): 581–9. doi:10.1007/s10165-009-0210-0. PMID 19697097.
- ↑ Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O (June 2016). "Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial". The Eurasian Journal of Medicine. 48 (2): 95–101. doi:10.5152/eurasianjmed.2015.15030. PMC 4970562. PMID 27551171.
External links
- Collagen+type+II at the US National Library of Medicine Medical Subject Headings (MeSH)
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