Cervical cancer differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2] Monalisa Dmello, M.B,B.S., M.D. [3]

Overview

Cervical cancer must be differentiated from other diseases that cause abnormal vaginal bleeding, such as cervical polyp, cervical leiomyoma, invasion of the cervix from primary uterine malignancy, vaginal cancer, cervical lymphoma, adenoma malignum, metastases to cervix, and cervical ectopic pregnancy.

Cervical cancer differential diagnosis

• Cervical cancer must be differentiated from a mass involving the cervix, and causing abnormal vaginal bleeding:

• Cervical polyp
• Cervical leiomyoma
• Cervical lymphoma

• Metastases to the cervix
• Cervical ectopic pregnancy
• Cervical polyp
• Cervicitis
• Cervical erosion ( Ectropion )

Diseases	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
	Symptoms			Physical examination
							Lab Findings			Imaging			Histopathology
	Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Cervical cancer
Cervical polyp
Cervical leiomyoma
Cervical lymphoma
Cervical sarcoma
Cervical erosion(Ectropion)
Cervicitis
IUD use
Pelvic inflammatory diseases
Nabothian cyst
Endometriosis
Adenomyosis
DES exposure ( Clear cell adenocarcinoma)
Postcoital bleeding