Rhabdomyosarcoma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
There are no established causes for rhabdomyosarcoma. Some of genetic disorders may be related to higher prevalence of rhabdomyosarcoma. Also some environmental factors, maternal history and birth characteristics may increase prevalence of rhabdomyosarcoma.
Causes
- The particular cause of rhabdomyosarcoma is not clear.[1][2]
- Some of genetic disorders may be related to higher prevalence of rhabdomyosarcoma:
- It is thought that some environmental factors may be associated to rhabdomyosarcoma such as:[3][4]
- Positive history of exposure to alkylating agent
- Parental x ray exposure
- Parental usage of recreational drugs (marijuana)
- It is thought that some maternal history and birth characteristics may be associated to rhabdomyosarcoma such as:[5][6]
- Maternal history of stillbirths
- High maternal age at childbirth
- High birth weight
References
- ↑ Arndt CA (2013). "Risk stratification of rhabdomyosarcoma: a moving target". Am Soc Clin Oncol Educ Book: 415–9. doi:10.1200/EdBook_AM.2013.33.415. PMID 23714563.
- ↑ Gripp KW (2005). "Tumor predisposition in Costello syndrome". Am J Med Genet C Semin Med Genet. 137C (1): 72–7. doi:10.1002/ajmg.c.30065. PMID 16010679.
- ↑ Grufferman S, Schwartz AG, Ruymann FB, Maurer HM (1993). "Parents' use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children". Cancer Causes Control. 4 (3): 217–24. PMID 8318638.
- ↑ Grufferman S, Ruymann F, Ognjanovic S, Erhardt EB, Maurer HM (2009). "Prenatal X-ray exposure and rhabdomyosarcoma in children: a report from the children's oncology group". Cancer Epidemiol Biomarkers Prev. 18 (4): 1271–6. doi:10.1158/1055-9965.EPI-08-0775. PMC 2773469. PMID 19293315.
- ↑ Ognjanovic S, Carozza SE, Chow EJ, Fox EE, Horel S, McLaughlin CC; et al. (2010). "Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype". Br J Cancer. 102 (1): 227–31. doi:10.1038/sj.bjc.6605484. PMC 2813761. PMID 19997102.
- ↑ Ghali MH, Yoo KY, Flannery JT, Dubrow R (1992). "Association between childhood rhabdomyosarcoma and maternal history of stillbirths". Int J Cancer. 50 (3): 365–8. PMID 1735603.