Hereditary nonpolyposis colorectal cancer secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Secondary prevention strategies following hereditary nonpolyposis colorectal cancer include genetic testing, colonoscopy, urine cytology, pelvic exam and endometrial biopsy.
Secondary prevention
Recent studies demonstrate a reduced incidence in hereditary nonpolyposis colorectal cancer patients who were exposed to at least four years of high-dose aspirin, with a satisfactory risk profile. These results have been widely covered in the media; future studies will look at modifying (lowering) the dose (to reduce risk associated with the high dosage of ASA).
Secondary prevention strategies following hereditary nonpolyposis colorectal cancer include:[1][2][3]
- Colonoscopy between 25-35 years, every 2 years.
- Pelvic exam, transvaginal ultrasound and CA-125 between 25-35 years, every year.
- Endometrial biopsy, in relation to clinical symptoms.
- Urine cytology (families who have someone diagnosed with transitional cell carcinoma of the ureter or renal pelvis, between 25-35 years every year)
References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.
- ↑ Lynch HT, Lynch PM, Lanspa SJ, Snyder CL, Lynch JF, Boland CR (2009). "Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications". Clin Genet. 76 (1): 1–18. doi:10.1111/j.1399-0004.2009.01230.x. PMC 2846640. PMID 19659756.
- ↑ Vasen HF, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G; et al. (1996). "Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis". Gastroenterology. 110 (4): 1020–7. PMID 8612988.