Neuroblastoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD [2]

Overview

In 1864, Rudolf Virchow (german physician) first described an abdominal tumor in a child as "glioma".
In 1891, Felix Marchand (german pathologist) described the characteristics of tumors from adrenal medulla and sympathetic nervous system.
In 1901, William Pepper described a neuroblastoma stage 4S presentation in infants that was metastatic to liver.
In 1910, James Homer Wright described circular clumps of cells in bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.