Nasopharyngeal carcinoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]
Overview
Historical Perspective
Discovery
- The association between EBV and nasopharyngeal carcinoma was made in1970.[1]
- In 1970, Zur Hausen and et al were the first to extract EBV DNA from NPC tumors by using DNA hybridization method.[2]
- In 1970, Henle and et al revealed the link between stage of NPC tumors and EBV antibody titer.[3]
- In 1973, Wolf and et al found EBV DNA in NPC tumor cells by in situ hybridization methods but not in infiltrating lymphoid cells.[4]
Famous Cases
Babe Ruth, a famous baseball player suffered from nasopharyngeal cancer.[5]
References
- ↑ H. zur Hausen, H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford & L. Santesson (1970). "EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx". Nature. 228 (5276): 1056–1058. PMID 4320657. Unknown parameter
|month=ignored (help) - ↑ H. zur Hausen, H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford & L. Santesson (1970). "EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx". Nature. 228 (5276): 1056–1058. PMID 4320657. Unknown parameter
|month=ignored (help) - ↑ W. Henle, G. Henle, H. C. Ho, P. Burtin, Y. Cachin, P. Clifford, A. de Schryver, G. de-The, V. Diehl & G. Klein (1970). "Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups". Journal of the National Cancer Institute. 44 (1): 225–231. PMID 11515035. Unknown parameter
|month=ignored (help) - ↑ H. Wolf, H. zur Hausen & V. Becker (1973). "EB viral genomes in epithelial nasopharyngeal carcinoma cells". Nature: New biology. 244 (138): 245–247. PMID 4353684. Unknown parameter
|month=ignored (help) - ↑ "10 Famous People Who Have Suffered from Head and Neck Cancer – Dr. Jeffrey Faulkner, ENT".