Duchenne muscular dystrophy natural history, complications and prognosis

Duchenne muscular dystrophy Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of Duchenne muscular dystrophy usually develop in the first decade of life, and start with symptoms such as muscle weakness and gait abnormalities.
• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

• Common complications of Duchenne muscular dystrophy include:
  • • Cardiomyopathy with heart failure
    • Cataracts
    • Decreased ability to care for self
    • Decreased movement
    • Depression
    • Respiratory failure
    • Contractures
    • Mental impairment (varies)
    • Scoliosis

Prognosis

• Prognosis is generally poor, and the mortality rate of patients with Duchenne muscular dystrophy is approximately 100%.
• The presence of low vital capacity or a sharp decline of vital capacity is associated with a particularly poor prognosis among patients with Duchenne muscular dystrophy.