Duchenne muscular dystrophy natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of Duchenne muscular dystrophy usually develop in the first decade of life, and start with symptoms such as muscle weakness and gait abnormalities.
- If left untreated, 100% of patients with Duchenne muscular dystrophy may progress to develop heart failure, respiratory failure, and death.
Complications
- Cardiomyopathy with heart failure
- Respiratory failure
- Cataracts
- Decreased movement
- Depression
- Contractures
- Mental impairment
- Scoliosis
- Failure to thrive
Prognosis
- Prognosis is generally poor, and the mortality rate of patients with Duchenne muscular dystrophy is approximately 100%.[5]
- The presence of low vital capacity or a sharp decline of vital capacity is associated with a particularly poor prognosis among patients with Duchenne muscular dystrophy.
References
- ↑ Nigro, G.; Comi, L.I.; Politano, L.; Bain, R.J.I. (1990). "The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy". International Journal of Cardiology. 26 (3): 271–277. doi:10.1016/0167-5273(90)90082-G. ISSN 0167-5273.
- ↑ Birnkrant DJ, Bushby K, Bann CM, Alman BA, Apkon SD, Blackwell A, Case LE, Cripe L, Hadjiyannakis S, Olson AK, Sheehan DW, Bolen J, Weber DR, Ward LM (April 2018). "Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management". Lancet Neurol. 17 (4): 347–361. doi:10.1016/S1474-4422(18)30025-5. PMC 5889091. PMID 29395990.
- ↑ Fitzpatrick, Carol; Barry, Ciaran; Garvey, Criona (2008). "PSYCHIATRIC DISORDER AMONG BOYS WITH DUCHENNE MUSCULAR DYSTROPHY". Developmental Medicine & Child Neurology. 28 (5): 589–595. doi:10.1111/j.1469-8749.1986.tb03900.x. ISSN 0012-1622.
- ↑ Smith AD, Koreska J, Moseley CF (August 1989). "Progression of scoliosis in Duchenne muscular dystrophy". J Bone Joint Surg Am. 71 (7): 1066–74. PMID 2760082.
- ↑ Visser, Jeldican; van den Berg-Vos, Renske M.; Franssen, Hessel; van den Berg, Leonard H.; Wokke, John H.; Vianney de Jong, J. M.; Holman, Rebecca; de Haan, Rob J.; de Visser, Marianne (2007). "Disease Course and Prognostic Factors of Progressive Muscular Atrophy". Archives of Neurology. 64 (4): 522. doi:10.1001/archneur.64.4.522. ISSN 0003-9942.