Melanocytic nevus pathophysiology

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Editors-In-Chief: Martin I. Newman, M.D., FACS, Cleveland Clinic Florida, [1];Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2] Michel C. Samson, M.D., FRCSC, FACS [3]

Overview

Melanocytic nevus is a benign growth on the skin (usually tan, brown, or flesh-colored) that contains a cluster of melanocytes and surrounding supportive tissue.

Pathophysiology

Congenital melanocytic nevi (CMN)

Congenital melanocytic nevi (CMN) are hamartomas lesions.
During embryogenesis clonal proliferations of benign melanocytes may give rise to melanocytic nevi.^[1]^[2]
BRAF V600E mutations have a very high corelation with small congenital melanocytic nevi (CMN), acquired melanocytic nevi and cutaneous melanomas.^[3]^[4]

Gross Pathology

References

↑ Tannous ZS, Mihm MC, Sober AJ, Duncan LM (February 2005). "Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management". J. Am. Acad. Dermatol. 52 (2): 197–203. doi:10.1016/j.jaad.2004.07.020. PMID 15692463.
↑ Price HN, Schaffer JV (2010). "Congenital melanocytic nevi-when to worry and how to treat: Facts and controversies". Clin. Dermatol. 28 (3): 293–302. doi:10.1016/j.clindermatol.2010.04.004. PMID 20541682.
↑ Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T (September 2006). "High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi". J. Invest. Dermatol. 126 (9): 2111–8. doi:10.1038/sj.jid.5700366. PMID 16691193.
↑ Wu J, Rosenbaum E, Begum S, Westra WH (December 2007). "Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis". Am J Dermatopathol. 29 (6): 534–7. doi:10.1097/DAD.0b013e3181584950. PMID 18032947.

Template:WikiDoc Sources

[pmid15692463-1] Tannous ZS, Mihm MC, Sober AJ, Duncan LM (February 2005). "Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management". J. Am. Acad. Dermatol. 52 (2): 197–203. doi:10.1016/j.jaad.2004.07.020. PMID 15692463.

[pmid20541682-2] Price HN, Schaffer JV (2010). "Congenital melanocytic nevi-when to worry and how to treat: Facts and controversies". Clin. Dermatol. 28 (3): 293–302. doi:10.1016/j.clindermatol.2010.04.004. PMID 20541682.

[pmid16691193-3] Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T (September 2006). "High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi". J. Invest. Dermatol. 126 (9): 2111–8. doi:10.1038/sj.jid.5700366. PMID 16691193.

[pmid18032947-4] Wu J, Rosenbaum E, Begum S, Westra WH (December 2007). "Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis". Am J Dermatopathol. 29 (6): 534–7. doi:10.1097/DAD.0b013e3181584950. PMID 18032947.

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