Melanocytic nevus natural history
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Editors-In-Chief: Martin I. Newman, M.D., FACS, Cleveland Clinic Florida, [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2]; Michel C. Samson, M.D., FRCSC, FACS [3]
Overview
Vast majority of moles are benign. Nonetheless, the National (U.S.) Cancer Institute reported 59,940 new cases of melanoma by June, 2007, with 8,110 deaths.[1]
Natural history of Congenital melanocytic nevi
- CMN grows as the child grows, with an approximate increase in size from infancy to adulthood in different regions of the body as follows:[2][3][4]
- Head – 1.7-fold
- Trunk and upper extremities – 2.8-fold
- Lower extremities – 3.3-fold
- CMN grows more quickly in early infancy.
- In addition to changes in size, CMN may change in appearance.
- Over the course f time CMN may change from flat, evenly pigmented patches to raised moles with a pebbly appearance, verrucous, or cerebriform surface, color may change from tan to darker, lighter, mottled, or uneven pigmentation.
Complications
Experts say that vast majority of moles are benign. Nonetheless, the National (U.S.) Cancer Institute reported 59,940 new cases of melanoma by June, 2007, with 8,110 deaths.[5]
References
- ↑ http://www.nci.nih.gov/cancertopics/types/melanoma
- ↑ Marghoob AA, Schoenbach SP, Kopf AW, Orlow SJ, Nossa R, Bart RS (February 1996). "Large congenital melanocytic nevi and the risk for the development of malignant melanoma. A prospective study". Arch Dermatol. 132 (2): 170–5. PMID 8629825.
- ↑ Rhodes AR, Albert LS, Weinstock MA (January 1996). "Congenital nevomelanocytic nevi: proportionate area expansion during infancy and early childhood". J. Am. Acad. Dermatol. 34 (1): 51–62. PMID 8543695.
- ↑ Ruiz-Maldonado R, Tamayo L, Laterza AM, Durán C (June 1992). "Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations". J. Pediatr. 120 (6): 906–11. PMID 1593350.
- ↑ http://www.nci.nih.gov/cancertopics/types/melanoma