Acinic cell carcinoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Natural History, Complications, and Prognosis
Natural History
- Parotid gland, is the most common site for acinic cell carcinoma affection.[1]
- Typically, acinic cell carcinoma is a slow growing mass, lacking other symptoms.[2][3]
- Pain or fixation to surroundings is a sign of poor prognosis.[4]
- Nodal metastasis of acinic cell carcinoma is extremely rare.
- Another rare complication is cranial nerve VII dysfunction.
- A small minority of of acinic cell carcinoma occurs in sinonasal area or larynx.
- There is a big controversy about bilateral acinic cell carcinoma, it is still unknown if it invades bilateral glands or just a unilateral tumor.[5][6][7]
- Common sites for non-salivary acinic cell carcinoma is lacrimal gland, pancreas, and breast.[8]
- Acinic cell carcinoma in pancreas are so called as acinar cell carcinoma.[9]
Complications
- growing mass in salivary glands
- Pain
- Fixation to surrounding tissue
- Dysphagia
- Hoarseness
- Cranial nerve VII involvement
- wight loss
Prognosis
- Acinar cell carcinoma has the best prognosis out of all salivary gland carcinomas.[10][11]
- The worst prognosis subtype is high-grade transformation type.
- Cure of acinic cell carcinoma prognosis varies from 89000 out of 100000 at 5 years to 55000 out of 100000 at 15 years.[12][13]
- Sever findings have suggested that a protracted cilinical course with reccurence occured years or even decades after initial diagnosis.
- The prognostic factors are :
- Age
- Pain
- Gender
- Race
- Perivious inadequate treatment
- Extent of disease.
- Invasion of the skull base.[14]
References
- ↑ "kankerregister.org" (PDF).
- ↑ Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
- ↑ Neskey, David M.; Klein, Jonah D.; Hicks, Stephanie; Garden, Adam S.; Bell, Diana M.; El-Naggar, Adel K.; Kies, Merrill S.; Weber, Randal S.; Kupferman, Michael E. (2013). "Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma". JAMA Otolaryngology–Head & Neck Surgery. 139 (11): 1195. doi:10.1001/jamaoto.2013.4728. ISSN 2168-6181.
- ↑ Ripamonti, Carla B; Colombo, Mara; Mondini, Patrizia; Siranoush, Manoukian; Peissel, Bernard; Bernard, Loris; Radice, Paolo; Carcangiu, Maria Luisa (2013). "First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: a case report". BMC Cancer. 13 (1). doi:10.1186/1471-2407-13-46. ISSN 1471-2407.
- ↑ Slater, Lee (2013). "Bilateral Multifocal Parotid Tumors: Acinic Cell Carcinomas Versus Nodular Oncocytic Hyperplasia". Journal of Oral and Maxillofacial Surgery. 71 (4): 655. doi:10.1016/j.joms.2012.12.022. ISSN 0278-2391.
- ↑ Gnepp, Douglas R.; Schroeder, Walter; Heffner, Dennis (1989). "Synchronous tumors arising in a single major salivary gland". Cancer. 63 (6): 1219–1224. doi:10.1002/1097-0142(19890315)63:6<1219::AID-CNCR2820630631>3.0.CO;2-Y. ISSN 0008-543X.
- ↑ Jia, Yu-Lin; Bishwo, Sedhain P.; Nie, Xiu; Chen, Li-Li (2012). "Synchronous Bilateral Multifocal Acinic Cell Carcinoma of Parotid Gland: Case Report and Review of the Literature". Journal of Oral and Maxillofacial Surgery. 70 (10): e574–e580. doi:10.1016/j.joms.2012.06.006. ISSN 0278-2391.
- ↑ Sen, Rajeev; Bhutani, Namita; Kamboj, Jashanpreet; Dahiya, Sakshi (2018). "Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype". Annals of Medicine and Surgery. 35: 137–140. doi:10.1016/j.amsu.2018.09.030. ISSN 2049-0801.
- ↑ Ilayaraja, Vadivel; Prasad, H; Anuthama, Krishnamurthy; Sruthi, Ranganath (2014). "Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation". Journal of Oral and Maxillofacial Pathology. 18 (1): 97. doi:10.4103/0973-029X.131925. ISSN 0973-029X.
- ↑ Patel, Neal R.; Sanghvi, Saurin; Khan, Mohemmed N.; Husain, Qasim; Baredes, Soly; Eloy, Jean Anderson (2013). "Demographic trends and disease‐specific survival in salivary acinic cell carcinoma: An analysis of 1129 cases". The Laryngoscope. 124 (1): 172–178. doi:10.1002/lary.24231. ISSN 0023-852X.
- ↑ Perzin, Karl H.; Livolsi, Virginia A. (1979). "Acinic cell carcinomas arising in salivary glands. A clinicopathologic study". Cancer. 44 (4): 1434–1457. doi:10.1002/1097-0142(197910)44:4<1434::AID-CNCR2820440439>3.0.CO;2-H. ISSN 0008-543X.
- ↑ Kane, W. J.; McCaffrey, T. V.; Olsen, K. D.; Lewis, J. E. (1991). "Primary Parotid Malignancies: A Clinical and Pathologic Review". Archives of Otolaryngology - Head and Neck Surgery. 117 (3): 307–315. doi:10.1001/archotol.1991.01870150075010. ISSN 0886-4470.
- ↑ Eneroth, Carl-Magnus; Jakobsson, Per Å.; Blanck, Carl (1966). "Acinic cell carcinoma of the parotid gland". Cancer. 19 (12): 1761–1772. doi:10.1002/1097-0142(196612)19:12<1761::AID-CNCR2820191202>3.0.CO;2-#. ISSN 0008-543X.
- ↑ Neff, Brian; Moore, Eric; Link, Michael; Carlson, Matthew; Breen, Joseph; Driscoll, Colin (2012). "Skull Base Involvement by Acinic Cell Carcinoma of the Parotid Gland". Journal of Neurological Surgery Part B: Skull Base. 73 (06): 371–378. doi:10.1055/s-0032-1322797. ISSN 2193-6331.