Subependymal giant cell astrocytoma MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Brain MRI is helpful in the diagnosis of subependymal giant cell astrocytoma. On MRI, subependymal giant cell astrocytoma is characterized by hypo- to isointensity on T1-weighted imaging and hyperintensity on T2-weighted imaging. There may be marked enhancement on contrast administration.

MRI

• Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma. Findings on MRI suggestive of/diagnostic of subependymal giant cell astrocytoma include:

• T1 isointense and hypointense signal enhancement
• T2 isointense and hyperintense signal enhancement
• Calcification

• Serial MRI every 1-3 years is recommended in patients younger than 25 as tumor growth is more common in these patients.

Gallery

• 
  _{Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.}
• 
  _{This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.}
• 
  _{Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.}

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