Secondary amyloidosis electrocardiogram
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
An ECG may be helpful in the diagnosis of secondary amyloidosis.
Electrocardiogram
- An ECG may be helpful in the diagnosis of secondary amyloidosis. Findings on an ECG suggestive of cardiac involvement include:[1]
- Voltage is lower than 5 mm in all limb leads.
- Other possible findings include:
- Left ventricular hypertrophy[2]
- Right ventricular hypertrophy[2]
- Left atrial abnormalities
- Pathological Q waves[2]
- Atrioventricular block: AV block occur due to deposition of amyloid fibrils in the conduction tissue.
- Cardiac involvement rarely occurs in the secondary amyloidosis and other possible cause should be ruled out first.[3]
References
- ↑ Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). "Systemic AA amyloidosis: epidemiology, diagnosis, and management". Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.
- ↑ 2.0 2.1 2.2 Damy T, Judge DP, Kristen AV, Berthet K, Li H, Aarts J (2015). "Cardiac findings and events observed in an open-label clinical trial of tafamidis in patients with non-Val30Met and non-Val122Ile hereditary transthyretin amyloidosis". J Cardiovasc Transl Res. 8 (2): 117–27. doi:10.1007/s12265-015-9613-9. PMC 4382536. PMID 25743445.
- ↑ Papa, Riccardo; Lachmann, Helen J. (2018). "Secondary, AA, Amyloidosis". Rheumatic Disease Clinics of North America. 44 (4): 585–603. doi:10.1016/j.rdc.2018.06.004. ISSN 0889-857X.