Secondary amyloidosis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The most potent risk factor in the development of secondary amyloidosis is a persistent inflammatory disorders.
Risk Factors
- The most potent risk factor in the development of secondary amyloidosis is a persistent inflammatory disorders.[1]
- chronic infections and inflammatory arthritis are among the most common risk factors.[2][3][4]
- Other possible risk factors include:
- Obesity
- Aging
- SAA1 gene alleles
- Monogenic periodic fever syndromes, such as:
- Conditions associated with increased risk of secondary amyloidosis include:
Chronic Infections Tuberculosis Leprosy Whipple Disease Osteomyelitis Chronic pyelonephritis Subacute bacterial endocarditis Chronic cutaneous ulcers Conditions Predisposing to Chronic Infections Cystic fibrosis Bronchiectasis Kartagener syndrome Epidermolysis bullosa Injected drug abuse Jejuno-ileal bypass Paraplegia Sickle cell anemia Immunodeficiency Common variable immunodeficiency Cyclic neutropenia Hyperimmunoglobulin M syndrome Hypogammaglobulinemia Sex-linked agammaglobulinemia Human immunodeficiency virus/AIDS Neoplasia Adenocarcinoma Basal cell carcinoma Carcinoid tumor Castleman disease Gastrointestinal stromal tumor Hairy cell leukemia Hepatic adenoma Hodgkin disease Mesothelioma Renal cell carcinoma Sarcoma Inflammatory Arthritis Adult-onset Still disease Ankylosing spondylitis Juvenile idiopathic arthritis Psoriatic arthropathy Reiter syndrome Rheumatoid arthritis Gout Systemic Vasculitis Antineutrophil cytoplasmic antibody-associated vasculitis Behc¸et disease Giant cell arteritis Polyarteritis nodosa Polymyalgia rheumatica Systemic lupus erythematosus Takayasu arteritis Periodic Fevers Cryopyrin-associated periodic fever syndrome Familial Mediterranean fever Mevalonate kinase deficiency Tumor necrosis factor receptor-associated periodic syndrome Inflammatory Bowel Disease Ulcerative colitis Crohn diseases Others Atrial myxoma Inflammatory abdominal aortic aneurism Retroperitoneal fibrosis SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome Sarcoidosis Sinus histiocytosis with massive lymphadenopathy
- ↑ Koivuniemi, Riitta; Paimela, Leena; Suomalainen, Risto; Törnroth, Tom; Leirisalo-Repo, Marjatta (2009). "Amyloidosis is frequently undetected in patients with rheumatoid arthritis". Amyloid. 15 (4): 262–268. doi:10.1080/13506120802524676. ISSN 1350-6129.
- ↑ Blank, Norbert; Hegenbart, Ute; Dietrich, Sascha; Brune, Maik; Beimler, Jörg; Röcken, Christoph; Müller-Tidow, Carsten; Lorenz, Hanns-Martin; Schönland, Stefan O. (2018). "Obesity is a significant susceptibility factor for idiopathic AA amyloidosis". Amyloid. 25 (1): 37–45. doi:10.1080/13506129.2018.1429391. ISSN 1350-6129.
- ↑ van der Hilst, J. C. H.; Yamada, T.; Op den Camp, H. J. M.; van der Meer, J. W. M.; Drenth, J. P. H.; Simon, A. (2008). "Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis". Rheumatology. 47 (11): 1651–1654. doi:10.1093/rheumatology/ken371. ISSN 1462-0324.
- ↑ Papa, Riccardo; Doglio, Matteo; Lachmann, Helen J.; Ozen, Seza; Frenkel, Joost; Simon, Anna; Neven, Bénédicte; Kuemmerle-Deschner, Jasmin; Ozgodan, Huri; Caorsi, Roberta; Federici, Silvia; Finetti, Martina; Trachana, Maria; Brunner, Jurgen; Bezrodnik, Liliana; Pinedo Gago, Mari Carmen; Maggio, Maria Cristina; Tsitsami, Elena; Al Suwairi, Wafaa; Espada, Graciela; Shcherbina, Anna; Aksu, Guzide; Ruperto, Nicolino; Martini, Alberto; Ceccherini, Isabella; Gattorno, Marco (2017). "A web-based collection of genotype-phenotype associations in hereditary recurrent fevers from the Eurofever registry". Orphanet Journal of Rare Diseases. 12 (1). doi:10.1186/s13023-017-0720-3. ISSN 1750-1172.