Beriberi laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]
Overview
The most sensitive lab tests to detect thiamine deficiency are measurements of erythrocyte transketolase activity (ETKA) and the thiamine pyrophosphate effect (TPPE).
Laboratory Findings
- The diagnosis of beriberi is assisted by a dietary history suggestive of a low thiamine intake and clinical manifestations.
- However, objective biochemical tests of thiamine status may assist with diagnosis.[1]
- Measurement of erythrocyte transketolase activity (ETKA) and the thiamine pyrophosphate effect (TPPE) are sensitive tests for thiamine deficiency.
- Other tests include measurements of urinary concetrations of thiamine and its metabolites, as well as methylglyoxal.
References
- ↑ Frank LL (2015). "Thiamin in Clinical Practice". JPEN J Parenter Enteral Nutr. 39 (5): 503–20. doi:10.1177/0148607114565245. PMID 25564426.