Central pontine myelinolysis primary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
To prevent central pontine myelinolysis in patients with hyponatremia, the hyponatremia should be corrected at a rate not exceeding 10 mmol/L/24 h or 0.5 mEq/L/h; or 18 mEq/L/48hrs to minimize the risk of this condition developing from the overly rapid reversal of hyponatremia, thus avoiding demyelination.
Primary Prevention
To prevent central pontine myelinolysis in patients with hyponatremia, the hyponatremia should be corrected at a rate not exceeding 10 mmol/L/24 h or 0.5 mEq/L/h; or 18 mEq/L/48hrs to minimize the risk of this condition developing from the overly rapid reversal of hyponatremia, thus avoiding demyelination.[1]
References
- ↑ Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D; et al. (2014). "Clinical practice guideline on diagnosis and treatment of hyponatraemia". Eur J Endocrinol. 170 (3): G1–47. doi:10.1530/EJE-13-1020. PMID 24569125.