Analgesic nephropathy natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal renal function after stopping the analgesic drug, however some may progress to end stage renal disease (ESRD). Complications of analgesic nephropathy include: urinary tract infections, varying degrees of renal failure and End stage renal disease (ESRD).
Natural History
- Renal function in most patients recovers to normal level after stopping the usage of analgesic drug if it is in the early stages of the disease.[1]
- Depending on the scarring and damage to the renal tissue, some patients may progress to end stage renal disease (ESRD), even after stopping the usage of analgesic drug.[1]
Complications
Complications of analgesic nephropathy include pyelonephritis[2] and end-stage kidney disease. Risk factors for poor prognosis include recurrent urinary tract infection and persistently elevated blood pressure. Analgesic nephropathy also appears to increase the risk of developing cancers of the urinary system.[3]
Complications associated with analgesic nephropathy include:[4][5]
- Urinary tract infections
- Varying degrees of renal failure
- End stage renal disease (ESRD)[1]
- Transitional cell tumours of the urothelium (in abuse of analgesics containing phenacetin)
Prognosis
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal renal function after stopping the analgesic drug, however some may progress to end stage renal disease (ESRD).[1]
References
- ↑ 1.0 1.1 1.2 1.3 "StatPearls". 2020. PMID 31082145.
- ↑ Maisonneuve P, Agodoa L, Gellert R; et al. (2000). "Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study". Am. J. Kidney Dis. 35 (1): 157–65. PMID 10620560. Unknown parameter
|month=ignored (help) - ↑ Blohmé I, Johansson S (1981). "Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic nephropathy". Kidney Int. 20 (5): 671–5. PMID 7045494. Unknown parameter
|month=ignored (help) - ↑ Nanra RS (1980). "Clinical and pathological aspects of analgesic nephropathy". Br J Clin Pharmacol. 10 Suppl 2: 359S–368S. doi:10.1111/j.1365-2125.1980.tb01824.x. PMC 1430193. PMID 7002190.
- ↑ Nanra RS, Stuart-Taylor J, de Leon AH, White KH (1978). "Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia". Kidney Int. 13 (1): 79–92. doi:10.1038/ki.1978.11. PMID 362034.