Analgesic nephropathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
There is a strong association between phenacetin and analgesic nephropathy which has led to the disappearing of classic analgesic nephropathy after the removal of phenacetin from the markets over 30 years ago. Although non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.
Causes
Phenacetin
- There is a strong association between phenacetin and analgesic nephropathy.[1]
- The classic analgesic nephropathy is disappearing after the removal of phenacetin from the markets over 30 years ago.[2]
NSAIDs, aspirin and acetaminophen
- Although non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.[1][3]
- Further randomized trials are required to assess the incidence of renal injury and analgesic nephropathy caused by certain drugs.[1]
References
- ↑ 1.0 1.1 1.2 Yaxley J (2016). "Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence". Korean J Fam Med. 37 (6): 310–316. doi:10.4082/kjfm.2016.37.6.310. PMC 5122661. PMID 27900067.
- ↑ Mihatsch MJ, Khanlari B, Brunner FP (2006). "Obituary to analgesic nephropathy--an autopsy study". Nephrol Dial Transplant. 21 (11): 3139–45. doi:10.1093/ndt/gfl390. PMID 16891638.
- ↑ Michielsen P (2007). "In memoriam 'analgesic nephropathy' (circa 1972-2006)". Nephrol Dial Transplant. 22 (4): 999–1001. doi:10.1093/ndt/gfl797. PMID 17213226.