Chorioamnionitis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
Clinical findings associated with chorioamnionitis include maternal fever, uterine tenderness, purulent/foul-smelling amniotic fluid, maternal/fetal tachycardia. Common fetal complications of chorioamnionitis include preterm birth, neonatal sepsis, neurologic complications, respiratory complications. Common maternal complications of chorioamnionitis include maternal sepsis, infections, and labor-related complications (e.g., cesarean section, postpartum hemorrhage, etc.)
Natural History
The symptoms of chorioamnionitis usually develop during the pregnancy, and start with symptoms such as maternal fever, uterine tenderness, purulent/foul-smelling amniotic fluid, maternal/fetal tachycardia.[1]
Complications
Fetal complications that can develop as a result of chorioamnionitis are:[2][3]
- Preterm birth
- Retinopathy of prematurity
- Neonatal sepsis
- Neonatal death
- Neurologic complications
- Respiratory complications
Maternal complications that can develop as a result of chorioamnionitis are:[3][1]
- Maternal sepsis
- Infections
- Severe pelvic infections and abscess
- Wound infections
- Endomyometritis
- Labor-related complications
Prognosis
The presence of cesarean delivery for dystocia, prolonged labor times (≥ 10 h), or administration of oxytocin during labor are associated with a particularly poor prognosis among infants exposed to chorioamnionitis.[4]
References
- ↑ 1.0 1.1 Tita AT, Andrews WW (June 2010). "Diagnosis and management of clinical chorioamnionitis". Clin Perinatol. 37 (2): 339–54. doi:10.1016/j.clp.2010.02.003. PMC 3008318. PMID 20569811.
- ↑ Ericson JE, Laughon MM (March 2015). "Chorioamnionitis: implications for the neonate". Clin Perinatol. 42 (1): 155–65, ix. doi:10.1016/j.clp.2014.10.011. PMC 4331454. PMID 25678002.
- ↑ 3.0 3.1 Fowler JR, Simon LV. PMID 30335284. Missing or empty
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(help) - ↑ Alexander JM, McIntire DM, Leveno KJ (August 1999). "Chorioamnionitis and the prognosis for term infants". Obstet Gynecol. 94 (2): 274–8. doi:10.1016/s0029-7844(99)00256-2. PMID 10432142.