Beta-thalassemia risk factors
|
Beta-thalassemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Beta-thalassemia risk factors On the Web |
|
American Roentgen Ray Society Images of Beta-thalassemia risk factors |
|
Risk calculators and risk factors for Beta-thalassemia risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Risk Factors
Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability of the mutated gene being inherited by an offspring. Even if a child does not have beta thalassemia major or intermedia, they can still be a carrier, possibly resulting in future generations of their offspring having beta thalassemia. Another risk factor is the ancestry. Beta thalassemia occurs most often in people of Italian, Greek, Middle Eastern, Southern Asian, and African ancestry[1].
Risk Factors in areas with high beta-thalassemia prevalence:
- Lack of awareness and education about the screening for beta-thalassemia
- Limited resources for screening programs
- Cultural and societal norms encouraging consanguineous marriage
- Consanguineous marriage in areas with a high prevalence of the disease
References
- ↑ Ward AJ, Cooper TA (January 2010). "The pathobiology of splicing". J Pathol. 220 (2): 152–63. doi:10.1002/path.2649. PMC 2855871. PMID 19918805.