Capillary leak syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

WikiDoc Resources for Capillary leak syndrome
Articles
Most recent articles on Capillary leak syndrome Most cited articles on Capillary leak syndrome Review articles on Capillary leak syndrome Articles on Capillary leak syndrome in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Capillary leak syndrome Images of Capillary leak syndrome Photos of Capillary leak syndrome Podcasts & MP3s on Capillary leak syndrome Videos on Capillary leak syndrome
Evidence Based Medicine
Cochrane Collaboration on Capillary leak syndrome Bandolier on Capillary leak syndrome TRIP on Capillary leak syndrome
Clinical Trials
Ongoing Trials on Capillary leak syndrome at Clinical Trials.gov Trial results on Capillary leak syndrome Clinical Trials on Capillary leak syndrome at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Capillary leak syndrome NICE Guidance on Capillary leak syndrome NHS PRODIGY Guidance FDA on Capillary leak syndrome CDC on Capillary leak syndrome
Books
Books on Capillary leak syndrome
News
Capillary leak syndrome in the news Be alerted to news on Capillary leak syndrome News trends on Capillary leak syndrome
Commentary
Blogs on Capillary leak syndrome
Definitions
Definitions of Capillary leak syndrome
Patient Resources / Community
Patient resources on Capillary leak syndrome Discussion groups on Capillary leak syndrome Patient Handouts on Capillary leak syndrome Directions to Hospitals Treating Capillary leak syndrome Risk calculators and risk factors for Capillary leak syndrome
Healthcare Provider Resources
Symptoms of Capillary leak syndrome Causes & Risk Factors for Capillary leak syndrome Diagnostic studies for Capillary leak syndrome Treatment of Capillary leak syndrome
Continuing Medical Education (CME)
CME Programs on Capillary leak syndrome
International
Capillary leak syndrome en Espanol Capillary leak syndrome en Francais
Business
Capillary leak syndrome in the Marketplace Patents on Capillary leak syndrome
Experimental / Informatics
List of terms related to Capillary leak syndrome

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Capillary Leak Syndrome or Systemic Capillary Leak Syndrome(SCLS). A rare medical condition where the number and size of the pores in the capillaries are increased which leads to a leakage of fluid from the blood to the interstitial fluid, resulting in dangerously low blood pressure (hypotension), edema and multiple organ failiure due to limited perfusion.

History

The syndrome was first described by Clarkson in 1960.

Symptoms

Edpisodes of

• Low blood pressure (hypotension)
• Hemoconcentration
• Hypoalbuminemia without albuminuria
• Generalized edema or anasarca

Treatment

The episode usually consists of two phases

1. The capillary leak phase (1-4 days) The initial phase is the capillary leak phase, lasting from 1 to 4 days. Clinical features are abdominal pain, nausea, generalized edema and hypotension that may result in cardiopulmonary collapse. Acute renal failure is due to acute tubular necrosis consequent to hypovolemia and rhabdomyolysis.

2. Recruitment of the interstitial fluid The second phase results in the recruitment of the initially extravasated fluid. Intravascular overload with polyuria and pulmonary edema often occur. Edema may be more severe due to massive fluid supply in the initial phase. It's necessary to monitor the patient in order to switch to depletion treatment with diuretics or hemofiltration.

Mortality is reported in 21% of the 57 cases described. However, better management of this condition has recently led to lower mortality. A few prophylactic treatments have been tried with variable results, principally terbutaline and theophyllin. Patients need to be monitored for monoclonal gammopathy since it may turn into multiple myeloma.

References

• Dorlands Medical Dictionary 30th Ed.
• Cancer.gov
• Case report in Oxford Journals
• Orphanet (2003)