PDGFA

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Platelet-derived growth factor alpha polypeptide, also known as PDGFA, is a human gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

Further reading

• Nath K, Gogi R, Khan AA, Hameed S (1978). "Vascular hamartoma and vascular tumours of orbit". Indian journal of ophthalmology. 25 (1): 18–23. PMID 612586.CS1 maint: Multiple names: authors list (link)
• Ishibashi T, Bottaro DP, Chan A; et al. (1993). "Expression cloning of a human dual-specificity phosphatase". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12170–4. doi:10.1073/pnas.89.24.12170. PMID 1281549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raines EW, Lane TF, Iruela-Arispe ML; et al. (1992). "The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1281–5. doi:10.1073/pnas.89.4.1281. PMID 1311092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson M, Ostman A, Bäckström G; et al. (1992). "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF". J. Biol. Chem. 267 (16): 11260–6. PMID 1317862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rorsman F, Leveen P, Betsholtz C (1993). "Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites". Growth Factors. 7 (3): 241–51. doi:10.3109/08977199209046928. PMID 1360804.CS1 maint: Multiple names: authors list (link)
• Stenman G, Rorsman F, Huebner K, Betsholtz C (1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet. Cell Genet. 60 (3–4): 206–7. doi:10.1159/000133337. PMID 1505216.CS1 maint: Multiple names: authors list (link)
• Wang Z, Lin XH, Qiu QQ, Deuel TF (1992). "Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease". J. Biol. Chem. 267 (24): 17022–31. PMID 1512241.CS1 maint: Multiple names: authors list (link)
• Bonthron D, Collins T, Grzeschik KH; et al. (1992). "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite". Genomics. 13 (2): 257–63. doi:10.1016/0888-7543(92)90240-S. PMID 1612586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takimoto Y, Wang ZY, Kobler K, Deuel TF (1991). "Promoter region of the human platelet-derived growth factor A-chain gene". Proc. Natl. Acad. Sci. U.S.A. 88 (5): 1686–90. doi:10.1073/pnas.88.5.1686. PMID 1848007.CS1 maint: Multiple names: authors list (link)
• Fabisiak JP, Evans JN, Absher M; et al. (1991). "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during remodeling". Chest. 99 (3 Suppl): 52S–54S. doi:10.1378/chest.99.3_Supplement.52S. PMID 1997274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mendoza AE, Young R, Orkin SH, Collins T (1990). "Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2177–81. doi:10.1073/pnas.87.6.2177. PMID 2315311.CS1 maint: Multiple names: authors list (link)
• Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH (1989). "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 4917–21. doi:10.1073/pnas.86.13.4917. PMID 2544881.CS1 maint: Multiple names: authors list (link)
• Rorsman F, Bywater M, Knott TJ; et al. (1988). "Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins". Mol. Cell. Biol. 8 (2): 571–7. PMID 2832727.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beckmann MP, Betsholtz C, Heldin CH; et al. (1988). "Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains". Science. 241 (4871): 1346–9. doi:10.1126/science.2842868. PMID 2842868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonthron DT, Morton CC, Orkin SH, Collins T (1988). "Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1492–6. doi:10.1073/pnas.85.5.1492. PMID 3422746.CS1 maint: Multiple names: authors list (link)
• Tong BD, Auer DE, Jaye M; et al. (1987). "cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains". Nature. 328 (6131): 619–21. doi:10.1038/328619a0. PMID 3614363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins T, Bonthron DT, Orkin SH (1987). "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain". Nature. 328 (6131): 621–4. doi:10.1038/328621a0. PMID 3614364.CS1 maint: Multiple names: authors list (link)
• Hoppe J, Schumacher L, Eichner W, Weich HA (1987). "The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related". FEBS Lett. 223 (2): 243–6. doi:10.1016/0014-5793(87)80297-1. PMID 3666150.CS1 maint: Multiple names: authors list (link)
• Betsholtz C, Johnsson A, Heldin CH; et al. (1986). "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines". Nature. 320 (6064): 695–9. doi:10.1038/320695a0. PMID 3754619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takimoto Y, Li WY, Wang ZY; et al. (1993). "Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene". Hiroshima J. Med. Sci. 42 (1): 47–52. PMID 8486521.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)