Diabetes with hypertension medical therapy

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Diabetes mellitus Main page

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Diabetes mellitus type 1
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]

Overview

Hypertension is a common co-morbidity associated with patients of diabetes, especially type 2 diabetes. Proper management of both these conditions are important to prevent future chronic complications like cardiovascular, nephrology and other complications.

Supportive trial data

Study name:LIFE study, 2002

  • Study design: Double blind, randomised, parallel-group trial
  • Sample size: 1195 patients with diabetes, hypertension, left-ventricular hypertrophy on electrocardiograms
  • Drugs: Losartan or Atenolol
  • Study period: 4 years
  • Study results: Losartan was found to be more effective than atenolol in reducing composite endpoints like cardiovascular morbidity and all causes mortality in patients with hypertension, diabetes, and left-ventricular hypertrophy.

Study name: Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial, (FACET), 1998

References

  1. Tatti P, Pahor M, Byington RP, Di Mauro P, Guarisco R, Strollo G; et al. (1998). "Outcome results of the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET) in patients with hypertension and NIDDM". Diabetes Care. 21 (4): 597–603. PMID 9571349.

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