Lepirudin (injection)

Lepirudin (injection)

Clinical data
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	SQ or IV
ATC code	B01AE02 (WHO)
Pharmacokinetic data
Bioavailability	100%
Elimination half-life	~1.3 hours
Excretion	Renal
Identifiers
CAS Number	120993-53-5
DrugBank	BTD00024
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C288H448N80O110S6
Molar mass	6983.5 g/mol

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Overview

Lepirudin (Refludan ®) is an anticoagulant which functions as a direct thrombin inhibitor.

It is derived from the saliva of the medicinal leech Hirudo medicinalis.

External links

• Hirudo Medicinalis TURKEY, Supplier of Hirudo Medicinalis
• Hirudo Medicinalis TURKEY
• Template:DiseasesDB
• Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes". Clin Appl Thromb Hemost. 11 (4): 371–4. PMID 16244762.CS1 maint: Multiple names: authors list (link)
• "Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin". Blood. PMID 16690967.
• Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3". J Thromb Haemost. 3 (11): 2428–36. PMID 16241940.CS1 maint: Multiple names: authors list (link)
• http://www.refludan.com/product/index.htm

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