Propacetamol

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Propacetamol
File:Propacetamol.svg
Clinical data
Routes of
administration		IV[1][2]
ATC code
Pharmacokinetic data
Elimination half-life2.4 hours [1]
ExcretionRenal
Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC14H2N2O3
Molar mass264.3202 g/mol

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Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V.. [2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol is given orally.[3] 2g of propacetamol are equivalent to 1g of paracetamol. [4]


References

  1. ↑ 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol". Br J Clin Pharmacol. 34 (1): 79–81. PMID 1633071. |access-date= requires |url= (help)
  2. ↑ 2.0 2.1 Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]". BMC Anesthesiol. 4 (1): 6. doi:10.1186/1471-2253-4-6. PMID 15367329. Retrieved 2008-04-01.
  3. ↑ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery". Br J Anaesth. 94 (5): 642–8. doi:10.1093/bja/aei109. PMID 15790675. Retrieved 2008-04-04.
  4. ↑ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". Int J Clin Pharmacol Ther. 42 (1): 50–7. PMID 14756388. |access-date= requires |url= (help)

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