Guillain-Barré syndrome physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2]
Overview
Guillain-Barré syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy affecting the peripheral nervous system, usually triggered by an acute infectious process. It is included in the wider group of peripheral neuropathies. There are several types of GBS, but unless otherwise stated, GBS refers to the most common form, acute inflammatory demyelinating polyneuropathy (AIDP). It is frequently severe and usually exhibits as an ascending paralysis noted by weakness in the legs that spreads to the upper limbs and the face along with complete loss of deep tendon reflexes. With prompt treatment of plasmapheresis followed by immunoglobulins and supportive care, the majority of patients will regain full functional capacity. However, death may occur if severe pulmonary complications and dysautonomia are present.
Physical examination
General physical examination
The findings on physical examination indicates features of autonomic dysfunction and weakness of respiratory muscles
Vitals
- Hyperthermia or hypothermia either could be present.
- Tachypnea due to respiratory failure could be observed.
- Tachycardia or bradycardia may be observed
- Hypertension or hypotension can be observed.
Neurological examination
Cranial nerve
- Facial palsy (cranial nerve VII involvement) is the most commonly found.
- Other findings like dysphagia (cranial nerve IX, X, and XI), dysarthria (cranial nerve X), ocular muscle palsy (VI), Ptosis (III}, and Pupillary abnormalities (Tonic pupils) (II) may be seen.
Motor system
Nutrition
The muscle bulk is normal earlier in the course of the disease. However, later with disease progression muscle atrophy may be found.
Tone
- Hypotonia may be seen associated with severe weakness
Power
- Progressive, symmetrical, ascending palsy involving proximal muscles earlier than distal muscles are the most common findings.
- The weakness usually starts with lower limb followed by trunk, upper limb, and cranial nerve. In Miller-Fischer variant though cranial nerves are involved earlier than the limbs.
Coordination
- The patient may have difficulty walking despite having a good power. This may be due to involvement of proprioceptive and ocular muscles involvement.
- Hypotonia may be seen
Sensory system
- Though the first presenting symptoms may be dysthesia but severe sensory involvement is unusal. A definitive sensory level findings put the diagnosis of GBS into question.
Reflexes
Hyporeflexia or Areflexia can be commonly seen
Diagnostic criteria
- Required
- Progressive, relatively symmetrical weakness of 2 or more limbs due to neuropathy
- Areflexia
- Disease course < 4 weeks
- Exclusion of other causes (see below)
- Supportive
- relatively symmetric weakness accompanied by numbness and/or tingling
- mild sensory involvement
- facial nerve or other cranial nerve involvement
- absence of fever
- typical CSF findings obtained from lumbar puncture
- electrophysiologic evidence of demyelination from electromyogram