CENPH

Centromere protein H
Identifiers
Symbols	CENPH ; PMF1; NNF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32519
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Centromere protein H, also known as CENPH, is a human gene.

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.

Further reading

• Sugata N, Li S, Earnshaw WC; et al. (2001). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes". Hum. Mol. Genet. 9 (19): 2919–26. PMID 11092768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saffery R, Sumer H, Hassan S; et al. (2003). "Transcription within a functional human centromere". Mol. Cell. 12 (2): 509–16. PMID 14536089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. PMID 15009096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Obuse C, Iwasaki O, Kiyomitsu T; et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mikami Y, Hori T, Kimura H, Fukagawa T (2005). "The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis". Mol. Cell. Biol. 25 (5): 1958–70. doi:10.1128/MCB.25.5.1958-1970.2005. PMID 15713649.CS1 maint: Multiple names: authors list (link)
• Tomonaga T, Matsushita K, Ishibashi M; et al. (2005). "Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy". Cancer Res. 65 (11): 4683–9. doi:10.1158/0008-5472.CAN-04-3613. PMID 15930286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foltz DR, Jansen LE, Black BE; et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada M, Cheeseman IM, Hori T; et al. (2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat. Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Izuta H, Ikeno M, Suzuki N; et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orthaus S, Ohndorf S, Diekmann S (2006). "RNAi knockdown of human kinetochore protein CENP-H". Biochem. Biophys. Res. Commun. 348 (1): 36–46. doi:10.1016/j.bbrc.2006.06.187. PMID 16875666.CS1 maint: Multiple names: authors list (link)
• Liao WT, Song LB, Zhang HZ; et al. (2007). "Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival". Clin. Cancer Res. 13 (2 Pt 1): 508–14. doi:10.1158/1078-0432.CCR-06-1512. PMID 17255272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)