PLAGL1

Pleiomorphic adenoma gene-like 1
Identifiers
Symbols	PLAGL1 ; DKFZp781P1017; LOT1; MGC126275; MGC126276; ZAC; ZAC1
External IDs	Template:OMIM5 HomoloGene: 31401
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLAGL1 207002 s at tn.png
File:PBB GE PLAGL1 207943 x at tn.png
File:PBB GE PLAGL1 209318 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pleiomorphic adenoma gene-like 1, also known as PLAGL1, is a human gene.

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications". Journal of deaf studies and deaf education. 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
• Abdollahi A, Roberts D, Godwin AK; et al. (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene. 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdollahi A, Godwin AK, Miller PD; et al. (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spengler D, Villalba M, Hoffmann A; et al. (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMID 9184226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Varrault A, Ciani E, Apiou F; et al. (1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. PMID 9671765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kas K, Voz ML, Hensen K; et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. PMID 9722527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdollahi A, Bao R, Hamilton TC (2000). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene. 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.CS1 maint: Multiple names: authors list (link)
• Kamiya M, Judson H, Okazaki Y; et al. (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. PMID 10655556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bilanges B, Varrault A, Mazumdar A; et al. (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene. 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.CS1 maint: Multiple names: authors list (link)
• Mackay DJ, Coupe AM, Shield JP; et al. (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abdollahi A, Pisarcik D, Roberts D; et al. (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffmann A, Ciani E, Boeckardt J; et al. (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. PMID 12529403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma D, Shield JP, Dean W; et al. (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI200419876. PMID 15286800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cvetkovic D, Pisarcik D, Lee C; et al. (2005). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitchell J, Punthakee Z, Lo B; et al. (2005). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome". Diabetologia. 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)