PTPN18

Protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
File:PBB Protein PTPN18 image.jpg PDB rendering based on 2oc3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2oc3​
Identifiers
Symbols	PTPN18 ; BDP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74971
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPN18 203555 at tn.png
File:PBB GE PTPN18 213521 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, non-receptor type 18 (brain-derived), also known as PTPN18, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The bilogical function of this PTP has not yet been determined.

Further reading

• Kim YW, Wang H, Sures I; et al. (1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene. 13 (10): 2275–9. PMID 8950995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spencer S, Dowbenko D, Cheng J; et al. (1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. PMID 9265651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dowbenko D, Spencer S, Quan C, Lasky LA (1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. PMID 9422760.CS1 maint: Multiple names: authors list (link)
• Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". J. Biol. Chem. 273 (46): 30487–96. PMID 9804817.CS1 maint: Multiple names: authors list (link)
• Wang B, Lemay S, Tsai S, Veillette A (2001). "SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF". Mol. Cell. Biol. 21 (4): 1077–88. doi:10.1128/MCB.21.4.1077-1088.2001. PMID 11158295.CS1 maint: Multiple names: authors list (link)
• Cong F, Spencer S, Côté JF; et al. (2001). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell. 6 (6): 1413–23. PMID 11163214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wise CA, Gillum JD, Seidman CE; et al. (2003). "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder". Hum. Mol. Genet. 11 (8): 961–9. PMID 11971877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiota M, Tanihiro T, Nakagawa Y; et al. (2004). "Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone". Mol. Endocrinol. 17 (4): 534–49. doi:10.1210/me.2002-0187. PMID 12554790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gensler M, Buschbeck M, Ullrich A (2004). "Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1". J. Biol. Chem. 279 (13): 12110–6. doi:10.1074/jbc.M309527200. PMID 14660651.CS1 maint: Multiple names: authors list (link)
• Aoki N, Ueno S, Mano H; et al. (2004). "Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation". J. Biol. Chem. 279 (11): 10765–75. doi:10.1074/jbc.M310401200. PMID 14679216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanchetot C, Chagnon M, Dubé N; et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tao WA, Wollscheid B, O'Brien R; et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gandhi TK, Chandran S, Peri S; et al. (2007). "A bioinformatics analysis of protein tyrosine phosphatases in humans". DNA Res. 12 (2): 79–89. doi:10.1093/dnares/12.2.79. PMID 16303740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)