RASD2
| RASD family, member 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | RASD2 ; MGC:4834; Rhes; TEM2 | ||||||||||
| External IDs | Template:MGI HomoloGene: 8628 | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
RASD family, member 2, also known as RASD2, is a human gene.[1]
This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[1]
References
Further reading
- Falk JD, Vargiu P, Foye PE; et al. (1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J. Neurosci. Res. 57 (6): 782–8. PMID 10467249.
- Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- St Croix B, Rago C, Velculescu V; et al. (2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. PMID 10947988.
- Chan SL, Monks LK, Gao H; et al. (2002). "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell". Br. J. Pharmacol. 136 (1): 31–6. doi:10.1038/sj.bjp.0704680. PMID 11976265.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vargiu P, De Abajo R, Garcia-Ranea JA; et al. (2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584.
- Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Taylor JP, Jackson DA, Morgan NG, Chan SL (2006). "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process". Biochem. Biophys. Res. Commun. 349 (2): 809–15. doi:10.1016/j.bbrc.2006.08.102. PMID 16945334.
- Agretti P, De Marco G, Pinchera A; et al. (2007). "Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells". J. Endocrinol. Invest. 30 (4): 279–84. PMID 17556863.
 | This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |