TOPBP1

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Topoisomerase (DNA) II binding protein 1
File:PBB Protein TOPBP1 image.jpg
PDB rendering based on 1wf6.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols TOPBP1 ; TOP2BP1
External IDs Template:OMIM5 Template:MGI HomoloGene: 38262
RNA expression pattern
File:PBB GE TOPBP1 202633 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Topoisomerase (DNA) II binding protein 1, also known as TOPBP1, is a human gene.[1]

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1".

Further reading

  • Nagase T, Seki N, Ishikawa K; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
  • Yamane K, Kawabata M, Tsuruo T (1997). "A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator". Eur. J. Biochem. 250 (3): 794–9. PMID 9461304.
  • Yamane K, Tsuruo T (1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA". Oncogene. 18 (37): 5194–203. doi:10.1038/sj.onc.1202922. PMID 10498869.
  • Mäkiniemi M, Hillukkala T, Tuusa J; et al. (2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response". J. Biol. Chem. 276 (32): 30399–406. doi:10.1074/jbc.M102245200. PMID 11395493.
  • Honda Y, Tojo M, Matsuzaki K; et al. (2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5): 3599–605. doi:10.1074/jbc.M104347200. PMID 11714696.
  • Yamane K, Wu X, Chen J (2002). "A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival". Mol. Cell. Biol. 22 (2): 555–66. PMID 11756551.
  • Boner W, Taylor ER, Tsirimonaki E; et al. (2002). "A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1". J. Biol. Chem. 277 (25): 22297–303. doi:10.1074/jbc.M202163200. PMID 11934899.
  • Herold S, Wanzel M, Beuger V; et al. (2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Mol. Cell. 10 (3): 509–21. PMID 12408820.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Liu K, Lin FT, Ruppert JM, Lin WC (2003). "Regulation of E2F1 by BRCT domain-containing protein TopBP1". Mol. Cell. Biol. 23 (9): 3287–304. PMID 12697828.
  • Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS (2003). "PML colocalizes with and stabilizes the DNA damage response protein TopBP1". Mol. Cell. Biol. 23 (12): 4247–56. PMID 12773567.
  • Yamane K, Chen J, Kinsella TJ (2003). "Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint". Cancer Res. 63 (12): 3049–53. PMID 12810625.
  • Greer DA, Besley BD, Kennedy KB, Davey S (2003). "hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation". Cancer Res. 63 (16): 4829–35. PMID 12941802.
  • Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science. 302 (5645): 636–9. doi:10.1126/science.1088877. PMID 14576432.
  • Yu X, Chini CC, He M; et al. (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–42. doi:10.1126/science.1088753. PMID 14576433.
  • Liu K, Luo Y, Lin FT, Lin WC (2004). "TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival". Genes Dev. 18 (6): 673–86. doi:10.1101/gad.1180204. PMID 15075294.
  • Reini K, Uitto L, Perera D; et al. (2005). "TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis". Chromosoma. 112 (7): 323–30. doi:10.1007/s00412-004-0277-5. PMID 15138768.
  • Hassel S, Eichner A, Yakymovych M; et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
  • Yoshida K, Inoue I (2004). "Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor". Oncogene. 23 (37): 6250–60. doi:10.1038/sj.onc.1207829. PMID 15195143.

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