Cretinism history and symptoms

Cretinism Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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History and Symptoms

Congenital hypothyroidism can be endemic, genetic, or sporadic. If untreated, it results in mild to severe impairment of both physical and mental growth and development.

Poor length growth is apparent as early as the first year of life. Adult stature without treatment ranges from 1 to 1.6 meters, depending on severity, sex and other genetic factors. Bone maturation and puberty are severely delayed. Ovulation is impeded and infertility common.