Adiposogenital dystrophy history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

It is characterized by:

• Feminine obesity
• Growth retardation and retarded sexual development, atrophy or hypoplasia of the gonads, and altered secondary sex characteristics,
• headaches
• mental retardation, problems with vision
• polyuria, polydipsia.

It is usually associated with tumours of the hypothalamus, causing increased appetite and depressed secretion of gonadotropin. It seems to affect males mostly.

Many overweight children may appear to have the disorder because of the concurrence of obesity and retarded sexual development; these children have no endocrine disturbances, however, and they mature normally after delayed puberty.