Hemophilia A overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hemophilia A is a blood clotting disorder caused by a mutation of the factor VIII gene, leading to a deficiency in Factor VIII. It is the most common hemophilia. Inheritance is X-linked recessive; hence, males are affected while females are carriers or very rarely display a mild phenotype. 1 in 5,000 males are affected.