Paroxysmal nocturnal hemoglobinuria overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Paroxysmal nocturnal hemoglobinuria is a rare, acquired, potentially life-threatening disease of the blood characterised byhemolytic anemia, thrombosis and red urine due to breakdown of red blood cells. PNH is the only hemolytic anemia caused by an acquired intrinsic defect in the cell membrane.