Diffuse panbronchiolitis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diffuse panbronchiolitis (DPB)[1] is an idiopathic (of unknown cause) inflammatory lung disease,[2] considered to be a type of COPD.[3][4] It is a severe, progressive form of bronchiolitis, mainly affecting the respiratory bronchioles (the section of the bronchioles involved in gas exchange).[2]
The term "diffuse" refers to the lesions which appear throughout both lungs, while the term "pan-" refers to the inflammation found in all layers of the respiratory bronchioles, both terms describing a common pathology for the disease.[2]
If left untreated, DPB is fatal, usually progressing to bronchiectasis, an irreversible lung conditon that causes respiratory failure.[2]
References
- ↑ Homma H, Yamanaka A, Tanimoto S, Tamura M, Chijimatsu Y, Kira S, Izumi T (1983). "Diffuse panbronchiolitis. A disease of the transitional zone of the lung". Chest. 83 (1): 63–69. PMID 6848335.
- ↑ 2.0 2.1 2.2 2.3 Poletti V, Casoni G, Chilosi M, Zompatori M (2006). "Diffuse panbronchiolitis". Eur Respir J. 28 (4): 862–871. PMID 17012632.
- ↑ Keicho N, Tokunaga K, Nakata K, Taguchi Y, Azuma A, Bannai M, Emi M, Ohishi N, Yazaki Y, Kudoh S (1998). "Contribution of HLA genes in genetic predisposition for diffuse panbronchiolitis". Am J Respir Crit Care Med. 158 (3): 846–850. PMID 9731015.
- ↑ Park MH, Kim YW, Yoon HI, Yoo CD, Han SK, Shim YS, Kim WD (1999). "Association of HLA class I antigens with diffuse panbronchiolitis in Korean patients". Am J Respir Crit Care Med. 159 (2): 526–529. PMID 9927368.