Congenital rubella syndrome pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: : Kalsang Dolma, M.B.B.S.[2]
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Congenital Rubella Syndrome Microchapters |
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Differentiating Congenital Rubella Syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Congenital rubella syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of Congenital rubella syndrome pathophysiology |
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Directions to Hospitals Treating Congenital rubella syndrome |
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Risk calculators and risk factors for Congenital rubella syndrome pathophysiology |
Overview
During maternal viraemic phase, rubella virus enters fetus through the placenta and cause damage to all germ layers of fetus. This results in rapid death of some cells. If infection occurs 0–28 days before conception, there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.