Creutzfeldt-Jakob disease MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Often shows high signal intensity in the caudate nucleus and putamen bilaterally on T2-weighted images.
Diffusion Weighted Imaging (DWI) images are the most sensitive. In about 24% of cases DWI shows only cortical hyperintensity; in 68%, cortical and subcortical abnormalities; and in 5%, only subcortical anomalies.^[1]
The involvement of the thalamus can be found in sCJD, even is stronger and constant in vCJD.^[2]
An abnormal signal in the posterior thalami on T2- and diffusion-weighted images and fluid-attenuated inversion recovery sequences on brain magnetic resonance imaging (MRI); in the appropriate clinical context, this signal is highly specific for vCJD. (Source: CDC)

↑ Young, Geoffrey S. (June–July 2005). "Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis". American Journal of Neuroradiology. American Society of Neuroradiology. 26: 1551–1562. Retrieved 2007-10-30. Unknown parameter |coauthors= ignored (help)CS1 maint: Date format (link)
↑ Tschampa, Henriette J. (May 2003). "Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study". American Journal of Neuroradiology. American Society of Neuroradiology. 24: 908–915. Retrieved 2007-10-30. Unknown parameter |coauthors= ignored (help)