Statin induced myopathy differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby
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Overview
Myalgia is a common complaint and should not be attributed directly to the use of statins. The patient should be evaluated for any thyroid problems, inflammatory processes, alcohol use, excessive exercise, electrolyte disturbances, side effects of other medications or vitamin deficiencies.
Differential Diagnosis
- Alcohol-related myopathy
- Arthritis
- Degenerative arthritis
- Inflammatory arthritis
- Connective tissue diseases
- Electrolyte abnormalities
- Hypokalemia
- Hypomagnesemia secondary to diuretic use
- Endocrine abnormalities
- Fibromyalgia
- Guillain-Barré syndrome
- Metabolic myopathies
- Carnitine palmitoyltransferase II (CPT II) deficiency
- McArdle disease
- Mitochondrial myopathies
- Muscle pain and myopathy from non-statin drugs
- Bisphosphonates
- Zidovudine (Retrovir)
- Vitamin E
- Myelopathy, spinal stenosis
- Myositis
- Peripheral neuropathy
- Peripheral vascular disease
- Progressive neuromuscular atrophy
- Vitamin D deficiency[1]
References
- ↑ Fernandez G, Spatz ES, Jablecki C, Phillips PS (2011). "Statin myopathy: a common dilemma not reflected in clinical trials". Cleve Clin J Med. 78 (6): 393–403. doi:10.3949/ccjm.78a.10073. PMID 21632911.