Fatty liver causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

Fatty liver is commonly associated with alcohol or metabolic syndrome (diabetes, hypertension and dyslipidemia) but can also be due to any one of many causes:

• Metabolic: Abetalipoproteinemia, glycogen storage diseases, Weber-Christian disease, Wolmans disease, acute fatty liver of pregnancy, lipodystrophy
• Nutritional: Malnutrition, total parenteral nutrition, severe weight loss, refeeding syndrome, jejuno-ileal bypass, gastric bypass, jejunal diverticulosis with bacterial overgrowth
• Drugs and toxins: Amiodarone, methotrexate, diltiazem, highly active antiretroviral therapy, glucocorticoids, tamoxifen, environmental hepatotoxins (e.g. phosphorus, toxic mushroom)
• Other: Inflammatory bowel disease, HIV

Causes in Alphabetical Order

3-alpha-hydroxyacyl-CoA dehydrogenase deficiency Abetalipoproteinaemia Acute fatty liver of pregnancy Alcohol Alpha1-antitrypsin deficiency Amiodarone Anti retroviral therapy Autoimmune hepatitis Carbon tetrachloride Chanarin-Dorfman disease Citrullinemia type 2 Congenital generalized lipodystrophy type 1 Congenital generalized lipodystrophy type 2 Cystic fibrosis Diabetes mellitus Diltiazem Ethanol Familial combined hyperlipidemia Fructose-1, 6-diphosphatase deficiency Galactosemia Gastric bypass Glucocorticoids Glycogen storage disorders Hepatitis C HIV Hypertriglyceridemia Hypobetalipoproteinemia Inflammatory bowel disease Iron overload

Jejunal diverticulosis with bacterial overgrowth Jejunoileal bypass Kwashiorkor Lipodystrophy Lomitapide Long-chain acyl-CoA dehydrogenase deficiency Malnutrition Medium chain acyl-CoA dehydrogenase deficiency Metabolic syndrome Methotrexate Mipomersen Mushroom poisoning Neutral lipid storage disease with myopathy Non alcoholic steatohepatitis Obesity Overnutrition Patent ductus venosus Phosphorous Refeeding syndrome Severe weight loss Tamoxifen Tetracycline Total parenteral nutrition Type II diabetes Tyrosinemia Valproic acid Very long-chain acyl-CoA dehydrogenase deficiency Weber-Christian disease Wilson disease