Lactic acidosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

• AIDS
• Cancer
• Drugs, toxins
• End-stage renal failure
• Fetal compromise during childbirth
• Glycogen storage disease
• Heart failure
• Heavy exercise
• Hypothermia
• Hypoventilation with hypercapnia
• Hypovolemia
• Infusions
• Leukemia
• Liver failure
• Myocardial Infarction
• Postoperative state
• Seizures
• Sepsis
• Severe anemia
• Severe thiamine deficiency
• Tumors
• Uncontrolled diabetes mellitus

Common Causes

• List the most common causes here.

Causes by Organ System

Cardiovascular	ST Elevation Myocardial Infarction Complications , Shock , Heart diseases , Cardiomyopathy , Cardiac arrest , Beriberi Heart Disease , Acute pulmonary edema
Chemical/Poisoning	Isopropyl alcohol , Ethanol , Cyanide intoxication , Crotalidae snake poisoning , Copperhead snake poisoning , Contrast medium , Complications During and Following Cardiac Catheterization, Carbon monoxide poisoning , Alcoholism
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Zalcitabine , Tenofovir , Telbivudine , Succinyl-CoA synthetase deficiency , Stavudine , Phenformin , Paracetamol , Metformin , Linezolid , Lamivudine , Glyburide and Metformin , Entecavir , Emtricitabine , Didanosine , Buformin , Biguanide , Atenolol , Ariboflavinosis , Adefovir , Abacavir , Abacavir
Ear Nose Throat	No underlying causes
Endocrine	Pheochromocytoma , Latent autoimmune diabetes , Hypoglycemia , Diabetic nephropathy , Diabetes mellitus
Environmental	Smoke inhalation
Gastroenterologic	Short bowel syndrome , Mesenteric ischemia , Liver disease , Intestinal ischaemia , Hepatic failure , Bacterial overgrowth of small intestine , Acute liver failure
Genetic	Type I Glycogen Storage Disease , Type 1 glycogen storage disease , SCHAD deficiency , Pyruvate dehydrogenase phosphatase deficiency , Pyruvate dehydrogenase deficiency, Pyruvate decarboxylase deficiency, Pyruvate carboxylase deficiency, Pyridoxine-5'-phosphate oxidase deficiency, Myopathy with deficiency of succinate dehydrogenase and aconitase, Mitochondrial genome inherited conditions, Mitochondrial encephalomyopathy -- aminoacidopathy , Mitochondrial DNA depletion syndrome , Mitochondrial aspartyl-tRNA synthetase deficiency , Medium and long chan 3-hydroxyacyl-coenzyme A dehydrogenase deficiency , Malonyl-CoA decarboxylase deficiency, Malonyl-CoA decarboxylase deficiency , Malignant hyperpyrexia, Hydroxyacyl-coa dehydrogenase type 2 deficiency , Holocarboxylase synthase deficiency , GRACILE syndrome ,Glycogenosis type 1b, Glycogenosis type 1a, Glycogen Storage Disease Type I , Glycogen storage disease type 1D , Glycogen storage disease type 1C , Fructose-1,6-bisphosphatase deficiency, , Fructose-1,6-diphosphatase deficiency, Fructose-1-phosphate aldolase deficiency, Fructose intolerance, Dihydrolipoamide dehydrogenase deficiency, Decreased activity of pyruvate dehydrogenase , Decreased activity pyruvate carboxylase , 3-methylglutaconic aciduria, type 4 , 3-Hydroxyisobutyric aciduria, 3-Hydroxyacyl-CoA Dehydrogenase II Deficiency , 17- beta-hydroxysteroid dehydrogenase X deficiency
Hematologic	Burkitt's lymphoma
Iatrogenic	No underlying causes
Infectious Disease	Sepsis , Acquired immune deficiency syndrome
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	Subacute necrotising encephalomyelopathy , Grand mal seizure , Ethylmalonic encephalopathy
Nutritional/Metabolic	Von Gierke Disease , Mitochondrial toxicity , Mitochondrial neurogastrointestinal encephalopathy syndrome , Mitochondrial myopathy , Impaired pyruvate utilization , Coenzyme Q10 deficiency
Obstetric/Gynecologic	Fetal distress
Oncologic	Non Hodgkin's lymphoma , Malignancy
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Severehypoxemia (PO2 <25 to 30 mmHg) , Severe asthma , Respiratory failure , Lung disease - reduced oxygen intake , Hypoxia
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Succinic acidemia , Strychnine , Severe exercise , Reye's syndrome , Reduced oxygen utilization , Multiple organ dysfunction , Marked acidemia , Intravenous pyelogram , Idiopathic , Hypothermic shivering , Hypoperfusion , Haemorrhage , Finnish lethal neonatal metabolic syndrome , Decreased oxygen delivery , Cuffed blood sample, Chronic fatigue syndrome

Causes in Alphabetical Order

Abacavir Abacavir Acquired immune deficiency syndrome Acute liver failure Acute pulmonary edema Adefovir Alcoholism Ariboflavinosis Atenolol Bacterial overgrowth of small intestine Beriberi Heart Disease Biguanide Buformin Burkitt's lymphoma Carbon monoxide poisoning Carbon monoxide poisoning Cardiac arrest Cardiomyopathy Chronic fatigue syndrome Coenzyme Q cytochrome c reductase deficiency Coenzyme Q10 deficiency Complications During and Following Cardiac Catheterization Contrast medium Copperhead snake poisoning Crotalidae snake poisoning Cuffed blood sample Cyanide intoxication [[Decreased activity pyruvate carboxylase [[Decreased activity of pyruvate dehydrogenase Decreased oxygen delivery Diabetes mellitus Diabetic nephropathy Didanosine Dihydrolipoamide dehydrogenase deficiency Dye-contrast medical tests - can cause LA by inhibiting the kidneys. Emtricitabine Entecavir Ethanol Ethylmalonic encephalopathy Fetal distress Finnish lethal neonatal metabolic syndrome Fire Fructose intolerance Fructose-1-phosphate aldolase deficiency Fructose-1, 6-diphosphatase deficiency

Fructose-1,6-bisphosphatase deficiency, hereditary Glyburide and Metformin Glycogen storage disease type 1C Glycogen storage disease type 1D Glycogen Storage Disease Type I Glycogenosis type 1a Glycogenosis type 1b GRACILE syndrome Grand mal seizure Haemorrhage Heart diseases Hemofiltration Hepatic failure Holocarboxylase synthase deficiency Hydroxyacyl-coa dehydrogenase, type 2, deficiency Hypoglycemia Hypoperfusion Hypothermic shivering Hypoxia Idiopathic Impaired pyruvate utilization Intestinal ischaemia Intravenous pyelogram Isopropyl alcohol Lamivudine Latent autoimmune diabetes Linezolid Liver disease Lung disease - reduced oxygen intake Malignancy Malignant hyperpyrexia Malonyl-CoA decarboxylase deficiency Malonyl-CoA decarboxylase deficiency Marked acidemia Medium and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency MELAS MERRF Mesenteric ischemia Metformin Mitochondrial aspartyl-tRNA synthetase deficiency Mitochondrial DNA depletion syndrome Mitochondrial encephalomyopathy -- aminoacidopathy Mitochondrial genome inherited conditions Mitochondrial myopathy

Mitochondrial neurogastrointestinal encephalopathy syndrome Mitochondrial toxicity Multiple organ dysfunction syndrome Myopathy with deficiency of succinate dehydrogenase and aconitase]] Non Hodgkin's lymphoma Paracetamol Phenformin Pheochromocytoma Pyridoxine-5'-phosphate oxidase deficiency Pyruvate carboxylase deficiency Pyruvate decarboxylase deficiency Pyruvate dehydrogenase deficiency Pyruvate dehydrogenase phosphatase deficiency Reduced oxygen utilization Renal failure, chronic Respiratory failure Reye's syndrome Salicylate intoxication SCHAD deficiency Sepsis Severe asthma Severe exercise Severe hypoxemia (PO2 <25 to 30 mmHg) Shock Short bowel syndrome Smoke inhalation ST Elevation Myocardial Infarction Complications Stavudine Strychnine Subacute necrotising encephalomyelopathy Succinic acidemia Succinyl-CoA synthetase deficiency Telbivudine Tenofovir Type 1 glycogen storage disease Type I Glycogen Storage Disease Von Gierke Disease Zalcitabine 17- beta-hydroxysteroid dehydrogenase X deficiency 3-Hydroxyacyl-CoA Dehydrogenase II Deficiency 3-Hydroxyisobutyric aciduria 3-methylglutaconic aciduria, type 4

References

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