Pulseless electrical activity natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Karol Gema Hernandez, M.D. [2]
Overview
PEA is associated with a poor prognosis, particularly if the underlying cause is not readily identified and treated. The presence of a QRS interval > 0.20 seconds is associated with a poorer prognosis. The survival of patients with PEA as a presenting rhythm for sudden cardiac arrest is poorer than ventricular tachycardia or ventricular fibrillation.[1]
Natural History, Complications and Prognosis
- The survival of patients with out of hospital occurrence of PEA is 19.5% compared to 11.2% among patients with in hospital PEA, likely due to the higher incidence of reversible causes among patients with out of hospital arrest.[1]
- Among 11,963 patients with PEA, only 11% survived, 62% of which had good neurological outcomes.[2]
- According to the Resuscitation Outcomes Consortium, the survival of patients with SCA during hospitalization is 8% among subjects with PEA compared to 30.5% for subjects with VT or VF; therefore, strategies for improving survival after PEA due to SCA should be implemented.
- However, Kudenchuk et al demonstrated an increase in overall survival from 2000 to 2004 with an odds ratio of 1.51 at 1 month (95% confidence interval [CI], 1.07–2.11), and 1.90 at 1 year (95% CI, 1.27–2.85).[3]
- According to Kudenchuk et al this increase in survival is attributed to the improvement of CPR techniques. However, this change in prevalence is unlikely because of improvement of response times. There are studies with different results, regarding response time. In the OPALS study (Ontario Prehospital Advanced Life Support) the increase of PEA cases occurred in a period of years where response times decreased.[4] A study made in Sweden by Herlitz et al, point out that the decrease in response timed correlated with the decrease of VT/VF and the increase of PEA. Teodorescu et al found no significant differences in response times between VF/VT, PEA, and asystolia.[5]
References
- ↑ 1.0 1.1 Meaney PA, Nadkarni VM, Kern KB, Indik JH, Halperin HR, Berg RA (2010). "Rhythms and outcomes of adult in-hospital cardiac arrest". Critical Care Medicine. 38 (1): 101–8. doi:10.1097/CCM.0b013e3181b43282. PMID 19770741. Retrieved 2012-09-16. Unknown parameter
|month=ignored (help) - ↑ Nadkarni VM, Larkin GL, Peberdy MA, Carey SM, Kaye W, Mancini ME; et al. (2006). "First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults". JAMA. 295 (1): 50–7. doi:10.1001/jama.295.1.50. PMID 16391216.
- ↑ Kudenchuk PJ, Redshaw JD, Stubbs BA, Fahrenbruch CE, Dumas F, Phelps R; et al. (2012). "Impact of changes in resuscitation practice on survival and neurological outcome after out-of-hospital cardiac arrest resulting from nonshockable arrhythmias". Circulation. 125 (14): 1787–94. doi:10.1161/CIRCULATIONAHA.111.064873. PMID 22474256.
- ↑ Stiell IG, Wells GA, Field BJ, Spaite DW, De Maio VJ, Ward R; et al. (1999). "Improved out-of-hospital cardiac arrest survival through the inexpensive optimization of an existing defibrillation program: OPALS study phase II. Ontario Prehospital Advanced Life Support". JAMA. 281 (13): 1175–81. PMID 10199426.
- ↑ Teodorescu C, Reinier K, Dervan C, Uy-Evanado A, Samara M, Mariani R; et al. (2010). "Factors associated with pulseless electric activity versus ventricular fibrillation: the Oregon sudden unexpected death study". Circulation. 122 (21): 2116–22. doi:10.1161/CIRCULATIONAHA.110.966333. PMID 21060069.