Niclosamide
| Niclosamide |
|---|
| YOMESAN® Package Insert |
| Clinical Pharmacology |
| Indications |
| Contraindications |
| Side Effects |
| Overdosage |
| Dosage |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide.
It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.
It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.
Niclosamide molecules are lethal to tapeworms upon contact.
Category
Anthelmintic
US Brand Names
NICLOCIDE, YOMESAN (DISCONTINUED)
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
According to an article in Nature,[1] niclosamide uncouples oxidative phosphorylation in the tapeworm.
References
- ↑ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.