Suppurative thrombophlebitis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Peripheral Vein
Suppurative thrombophlebitis usually occur in peripheral veins as a result of an intravenous catheter or peripherally inserted central venous catheter. Other causes may include intravenous drug use, abrasions and lacerations, soft-tissue infection, hypercoagulable states, and burns.
The high risk of Suppurative thrombophlebitis in burn patients is explained by the high skin susceptibility to bacterial infection, use of broad spectrum antibiotics, and impairment of local defense due to loss of skin integrity.[1]
Staphylococcus aureus has been documented as the most common cause of suppurative thrombophlebitis affecting the peripheral veins.[2] Other documented organisms include streptococci, and enterobacteria.[3]
Lemierre's syndrome
Lemierre's syndrome also known as jugular vein suppurative thrombophlebitis,postanginal sepsis, and necrobacillosis.[4] There is extension of the bacterial infection from pharyngitis, tonsillitis, or peri-tonsillar infection, to the carotid sheath vessels that contain that contains the internal jugular vein resulting in bacteremia.[5]
References
- ↑ Pruitt BA, McManus WF, Kim SH, Treat RC (1980). "Diagnosis and treatment of cannula-related intravenous sepsis in burn patients". Ann Surg. 191 (5): 546–54. PMC 1344732. PMID 7369818.
- ↑ Baker CC, Petersen SR, Sheldon GF (1979). "Septic phlebitis: a neglected disease". Am J Surg. 138 (1): 97–103. PMID 464215.
- ↑ Khan EA, Correa AG, Baker CJ (1997). "Suppurative thrombophlebitis in children: a ten-year experience". Pediatr Infect Dis J. 16 (1): 63–7. PMID 9002104.
- ↑ Riordan T, Wilson M (2004). "Lemierre's syndrome: more than a historical curiosa". Postgrad Med J. 80 (944): 328–34. PMC 1743018. PMID 15192164.
- ↑ Sinave CP, Hardy GJ, Fardy PW (1989). "The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection". Medicine (Baltimore). 68 (2): 85–94. PMID 2646510.