Creutzfeldt-Jakob disease other diagnostic studies
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
|
Creutzfeldt-Jakob disease Microchapters |
|
Differentiating Creutzfeldt-Jakob disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Creutzfeldt-Jakob disease other diagnostic studies On the Web |
|
American Roentgen Ray Society Images of Creutzfeldt-Jakob disease other diagnostic studies |
|
Creutzfeldt-Jakob disease other diagnostic studies in the news |
|
Risk calculators and risk factors for Creutzfeldt-Jakob disease other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
EEG findings of triphasic spikes have been included by CDC in the diagnostic criteria for probable Creutzfeldt-Jakob disease.[1]
Other Diagnostic Studies
Electroencephalography
EEG findings are not diagnostic of CJD but they are supportive of a probable diagnosis of CJD. Periodic synchronous discharges (PSDs) occur either before or in synchronicity with myoclonus.[2] Typical EEG findings in CJd include:
- Periodic bi or triphasic sharp wave complexes (PSWCs)
PSWCs can differentiate sporadic CJD from other types of CJD and other prion diseases. They are not present in variant CJD and only rarely present in familial CJD. They are absent in Kuru, Gerstmann-Sträussler-Scheinker syndrome and fatal familial insomnia.[3]
Biopsy
In one third of patients with sporadic CJD, deposits of prion protein (scrapie), PrPSc, can be found in the skeletal muscle and/or the spleen. Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbor significant amounts of PrpSc; however, biopsy of brain tissue is the definitive diagnostic test.
References
- ↑ "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in
|title=(help) - ↑ Hayashi, R.; Hanyu, N.; Kuwabara, T.; Moriyama, S. (1992). "Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease". Acta Neurol Scand. 85 (3): 161–5. PMID 1574996. Unknown parameter
|month=ignored (help) - ↑ Steinhoff, BJ.; Zerr, I.; Glatting, M.; Schulz-Schaeffer, W.; Poser, S.; Kretzschmar, HA. (2004). "Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease". Ann Neurol. 56 (5): 702–8. doi:10.1002/ana.20261. PMID 15449324. Unknown parameter
|month=ignored (help)