Kaposi's sarcoma natural history
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Kaposi's sarcoma Microchapters |
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Natural History
Kaposi's sarcoma-associated herpesvirus (KSHV) infection does not always lead to Kaposi sarcoma (KS); it is still unclear what other factors may be required, such as pre-existing immune system damage, or a specific interaction with HIV or other viruses. However, research in Africa has shown that even in the absence of HIV/AIDS, KS is more common in men than women although KSHV infection is equal between both sexes. This suggests that sex hormones may either protect from or predispose to KS in persons infected with the virus. Growth can range from very slow to explosively fast, and be associated with significant mortality and morbidity.
Prognosis
The prognosis of Kaposi's sarcoma depends on the following:
- The type of Kaposi sarcoma
- Whether the cancer has spread
- Whether the cancer has just been diagnosed or has recurred
- The patient's general health, especially the immune system.
5-Year Survival
- Between 2004 and 2010, the 5-year relative survival of patients with Kaposi sarcoma was 72%.[1]
- When stratified by age, the 5-year relative survival of patients with Kaposi sarcoma was 68.6% and 87.5% for patients <65 and ≥ 65 years of age respectively.[1]
References
- ↑ 1.0 1.1 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.